3zn3 | pdb_00003zn3

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Template:STRUCTURE 3zn3

N-terminal domain of S. pombe Cdc23 APC subunit

Template:ABSTRACT PUBMED 23583778

Function

[APC8_SCHPO] Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.[1]

About this Structure

3zn3 is a 1 chain structure with sequence from Cbs 356. Full crystallographic information is available from OCA.

Reference

  1. Zhang Z, Chang L, Yang J, Conin N, Kulkarni K, Barford D. The Four Canonical TPR Subunits of Human APC/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a TPR Suprahelix. J Mol Biol. 2013 Apr 11. pii: S0022-2836(13)00233-7. doi:, 10.1016/j.jmb.2013.04.004. PMID:23583778 doi:https://dx.doi.org/10.1016/j.jmb.2013.04.004
  1. ↑ Yamashita YM, Nakaseko Y, Kumada K, Nakagawa T, Yanagida M. Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses. Genes Cells. 1999 Aug;4(8):445-63. PMID:10526233

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