4m2s | pdb_00004m2s

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Template:STRUCTURE 4m2s

Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR

Template:ABSTRACT PUBMED 24155053

Function

[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.[1]

About this Structure

4m2s is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. Li J, Jaimes KF, Aller SG. Refined structures of mouse P-Glycoprotein. Protein Sci. 2013 Oct 24. doi: 10.1002/pro.2387. PMID:24155053 doi:https://dx.doi.org/10.1002/pro.2387
  1. ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718

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