3ilb | pdb_00003ilb
From Proteopedia
Crystal structure of mouse Bcl-xl mutant (R139A) at pH 6.0
Function
[B2CL1_MOUSE] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.[1] Isoform Bcl-X(S) promotes apoptosis (By similarity).[2]
About this Structure
3ilb is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
See Also
Reference
- Priyadarshi A, Roy A, Kim KS, Kim EE, Hwang KY. Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol. Biochem Biophys Res Commun. 2010 Apr 9;394(3):515-21. Epub 2010 Mar 4. PMID:20206602 doi:10.1016/j.bbrc.2010.03.002
- ↑ Yang XF, Weber GF, Cantor H. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 1997 Nov;7(5):629-39. PMID:9390687
- ↑ Yang XF, Weber GF, Cantor H. A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells. Immunity. 1997 Nov;7(5):629-39. PMID:9390687
