3td8 | pdb_00003td8
From Proteopedia
Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1-pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine
Function
[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
3td8 is a 1 chain structure with sequence from Pneca. Full crystallographic information is available from OCA.
See Also
Reference
- Cody V, Pace J, Stewart E. Structural analysis of Pneumocystis cariniidihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d] pyrimidine. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):418-23., Epub 2012 Mar 28. PMID:22505410 doi:10.1107/S1744309112008688
