4c8t | pdb_00004c8t
From Proteopedia
Xenopus ZNRF3 ectodomain crystal form I
Function
[ZNRF3_XENTR] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components (By similarity).
About this Structure
4c8t is a 2 chain structure with sequence from Silurana (xenopus) tropicalis. Full crystallographic information is available from OCA.
Reference
- Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY. Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776 doi:https://dx.doi.org/10.1038/ncomms3787
