Sandbox Reserved 765

This Sandbox is Reserved from Sep 25, 2013, through Mar 31, 2014 for use in the course "BCH455/555 Proteins and Molecular Mechanisms" taught by Michael B. Goshe at the North Carolina State University. This reservation includes Sandbox Reserved 299, Sandbox Reserved 300 and Sandbox Reserved 760 through Sandbox Reserved 779.

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Chorismate Synthase

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spinqualitylabelsall models Structure of HMG-CoA reductase (PDB entry 1dq8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D General Information Scientific Name: Aquifex aeolicus Genus: Aquifex Gene: Aroc Formula weight: 44,931.7 Classification: Lyase Length: 401 residues Isoelectric point: 5.5 Chains: A,B,C,D Contagious diseases are increasingly becoming a major public health issue. The shikimate pathway is often used for the advancement of antimicrobial mixures to fight against these diseases. This process only takes place prokaryotes, fungi and plants. Chorismate synthase is the enzyme that is used in the shikimate pathway, which catalyzes the coversion of phosphoenol pyruvate to chorismate. Chorismate Synthase is an enzyme part of the lyase family. Studying this enzyme and the roles that it plays in many diseases, inhibition of this reaction can lead to oral treatment for infectious diseases. This enzyme is responsible for catalyzing the following reversible reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate <--> Chorismate + Phosphate.