4ixv | pdb_00004ixv
From Proteopedia
Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)
Function
[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
About this Structure
4ixv is a 3 chain structure. Full crystallographic information is available from OCA.
Reference
- Golebiowski A, Whitehouse D, Beckett RP, Van Zandt M, Ji MK, Ryder TR, Jagdmann E, Andreoli M, Lee Y, Sheeler R, Conway B, Olczak J, Mazur M, Czestkowski W, Piotrowska W, Cousido-Siah A, Ruiz FX, Mitschler A, Podjarny A, Schroeter H. Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4837-41. doi: 10.1016/j.bmcl.2013.06.092., Epub 2013 Jul 8. PMID:23886684 doi:https://dx.doi.org/10.1016/j.bmcl.2013.06.092
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Arginase
- Andreoli, M.
- Beckett, P.
- Cousido-Siah, A.
- Czestkowski, W.
- Golebiowski, A.
- Jagdmann, R.
- Ji, M K.
- Mazur, M.
- Mitschler, A.
- Olczak, J.
- Piotrowska, W.
- Podjarny, A.
- Ruiz, F X.
- Ryder, T.
- Schroeter, H.
- Whitehouse, D.
- Zandt, M C.Van.
- Alpha/beta fold
- Arginine metabolism
- Hydrolase
- Hydrolase-hydrolase inhibitor complex
- Metalloenzyme
- Mitochondrion
