1v7f | pdb_00001v7f
From Proteopedia
Solution structure of phrixotoxin 1
Template:ABSTRACT PUBMED 15096626
Function
[TXP1_PARSR] Potently blocks A-type potassium currents. Specifically blocks Kv4.2/KCND2 and Kv4.3/KCND3 channels by altering the gating properties of these channels.[1]
About this Structure
1v7f is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Chagot B, Escoubas P, Villegas E, Bernard C, Ferrat G, Corzo G, Lazdunski M, Darbon H. Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci. 2004 May;13(5):1197-208. PMID:15096626 doi:10.1110/ps.03584304
- ↑ Diochot S, Drici MD, Moinier D, Fink M, Lazdunski M. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br J Pharmacol. 1999 Jan;126(1):251-63. PMID:10051143 doi:https://dx.doi.org/10.1038/sj.bjp.0702283
