4ie3 | pdb_00004ie3
From Proteopedia
Crystal structure of human Arginase-2 complexed with inhbitor 1o
Template:ABSTRACT PUBMED 23453840
Function
[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
About this Structure
4ie3 is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Golebiowski A, Paul Beckett R, Van Zandt M, Ji MK, Whitehouse D, Ryder TR, Jagdmann E, Andreoli M, Mazur A, Padmanilayam M, Cousido-Siah A, Mitschler A, Ruiz FX, Podjarny A, Schroeter H. 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2027-30. doi: 10.1016/j.bmcl.2013.02.024. , Epub 2013 Feb 13. PMID:23453840 doi:https://dx.doi.org/10.1016/j.bmcl.2013.02.024
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Arginase
- Human
- Andreoli, M.
- Beckett, P.
- Cousido-Siah, A.
- Golebiowski, A.
- Jagdmann, E.
- Ji, M K.
- Mazur, A.
- Mitschler, A.
- Padmanilayam, M.
- Podjarny, A.
- Ruiz, F X.
- Ryder, T.
- Schroeter, H.
- Whitehouse, D.
- Zandt, M C.Van.
- Alpha/beta fold
- Arginine metabolism
- Hydrolase
- Hydrolase-hydrolase inhibitor complex
- Manganese
- Metalloenzyme
- Mitochondrion
