4n5d | pdb_00004n5d
From Proteopedia
Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1
Template:ABSTRACT PUBMED 24259468
Function
[CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
About this Structure
4n5d is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Tailoring Small Molecules for an Allosteric Site on Procaspase-6. ChemMedChem. 2013 Nov 20. doi: 10.1002/cmdc.201300424. PMID:24259468 doi:https://dx.doi.org/10.1002/cmdc.201300424
