4kr1 | pdb_00004kr1
From Proteopedia
Crystal structure of the kinetechore protein Iml3 from budding yeast
Template:ABSTRACT PUBMED 24311582
Function
[IML3_YEAST] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.[1] [2]
About this Structure
4kr1 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Guo Q, Tao Y, Liu H, Teng M, Li X. Structural insights into the role of the Chl4-Iml3 complex in kinetochore assembly. Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2412-9. doi:, 10.1107/S0907444913022397. Epub 2013 Nov 19. PMID:24311582 doi:https://dx.doi.org/10.1107/S0907444913022397
- ↑ Ghosh SK, Poddar A, Hajra S, Sanyal K, Sinha P. The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Mol Genet Genomics. 2001 Apr;265(2):249-57. PMID:11361335
- ↑ Ghosh SK, Sau S, Lahiri S, Lohia A, Sinha P. The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Curr Genet. 2004 Aug;46(2):82-91. Epub 2004 Jul 6. PMID:15241623 doi:https://dx.doi.org/10.1007/s00294-004-0516-6
