2mf8 | pdb_00002mf8
From Proteopedia
HADDOCK model of MyT1 F4F5 - DNA complex
Template:ABSTRACT PUBMED 24097990
Function
[MYT1_MOUSE] Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).[1]
About this Structure
2mf8 is a 3 chain structure with sequence from Lk3 transgenic mice. Full experimental information is available from OCA.
Reference
- Gamsjaeger R, O'Connell MR, Cubeddu L, Shepherd NE, Lowry JA, Kwan AH, Vandevenne M, Swanton MK, Matthews JM, Mackay JP. A structural analysis of DNA binding by Myelin Transcription Factor 1 double zinc fingers. J Biol Chem. 2013 Oct 6. PMID:24097990 doi:https://dx.doi.org/10.1074/jbc.M113.482075
- ↑ Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD. Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. J Neurosci Res. 1997 Oct 15;50(2):272-90. PMID:9373037
