4hn4 | pdb_00004hn4
From Proteopedia
Tryptophan synthase in complex with alpha aminoacrylate E(A-A) form and the F9 inhibitor in the alpha site
Template:ABSTRACT PUBMED 23952479
Function
[TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [TRPB_SALTY] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
About this Structure
4hn4 is a 2 chain structure with sequence from [1] and Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA.
Reference
- Niks D, Hilario E, Dierkers A, Ngo H, Borchardt D, Neubauer TJ, Fan L, Mueller LJ, Dunn MF. Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry. 2013 Sep 17;52(37):6396-411. doi: 10.1021/bi400795e. Epub 2013 Sep , 6. PMID:23952479 doi:https://dx.doi.org/10.1021/bi400795e
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Salmonella enterica subsp. enterica serovar typhimurium
- Tryptophan synthase
- Dunn, M F.
- Fan, L.
- Hilario, E.
- Mueller, L J.
- Niks, D.
- Allosteric enzyme
- Alpha amino acrylate
- Amino-acid biosynthesis
- Aromatic amino acid biosynthesis
- Carbon-oxygen lyase
- F9f
- Lyase
- Lyase-lyase inhibitor complex
- Pyridoxal phosphate
- Salmonella
- Tryptophan biosynthesis
