4ia0 | pdb_00004ia0
From Proteopedia
Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Template:ABSTRACT PUBMED 23867165
Function
[PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
About this Structure
4ia0 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. , Epub 2013 Jun 29. PMID:23867165 doi:https://dx.doi.org/10.1016/j.bmcl.2013.06.062
