3hj3 | pdb_00003hj3

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Template:STRUCTURE 3hj3

Crystal Structure of the ChTS-DHFR F207A Non-Active Site Mutant

Template:ABSTRACT PUBMED 24324854

Function

[Q5CGA3_CRYHO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]

About this Structure

3hj3 is a 4 chain structure with sequence from Cryho. Full crystallographic information is available from OCA.

See Also

Reference

  1. Martucci WE, Rodriguez JM, Vargo MA, Marr M, Hamilton AD, Anderson KS. Exploring novel strategies for AIDS protozoal pathogens: alpha-helix mimetics targeting a key allosteric protein-protein interaction in TS-DHFR. Medchemcomm. 2013 Sep;4(9). doi: 10.1039/C3MD00141E. PMID:24324854 doi:https://dx.doi.org/10.1039/C3MD00141E

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OCA

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