2yab | pdb_00002yab
Crystal structure of the autoinhibited form of mouse DAPK2 in complex with AMP
Template:ABSTRACT PUBMED 21497605
Function
[DAPK2_MOUSE] Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity).[UniProtKB:P53355][UniProtKB:Q9UIK4]
About this Structure
2yab is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
See Also
Reference
- Patel AK, Yadav RP, Majava V, Kursula I, Kursula P. Structure of the Dimeric Autoinhibited Conformation of DAPK2, a Pro-Apoptotic Protein Kinase. J Mol Biol. 2011 Apr 8. PMID:21497605 doi:10.1016/j.jmb.2011.03.065
