4lli | pdb_00004lli
Crystal Structure of human Myosin 5a globular domain
Template:ABSTRACT PUBMED 24339992
Disease
[MYO5A_HUMAN] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
Function
[MYO5A_HUMAN] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.[1]
About this Structure
4lli is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Velvarska H, Niessing D. Structural insights into the globular tails of the human type v myosins myo5a, myo5b, and myo5c. PLoS One. 2013 Dec 10;8(12):e82065. doi: 10.1371/journal.pone.0082065. PMID:24339992 doi:https://dx.doi.org/10.1371/journal.pone.0082065
- ↑ Mehta AD, Rock RS, Rief M, Spudich JA, Mooseker MS, Cheney RE. Myosin-V is a processive actin-based motor. Nature. 1999 Aug 5;400(6744):590-3. PMID:10448864 doi:https://dx.doi.org/10.1038/23072
