4dwq | pdb_00004dwq
From Proteopedia
RNA ligase RtcB-GMP/Mn(2+) complex
Template:ABSTRACT PUBMED 22949672
Function
[RTCB_PYRHO] tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity).
About this Structure
4dwq is a 2 chain structure with sequence from 'pyrococcus shinkaii'. Full crystallographic information is available from OCA.
Reference
- Englert M, Xia S, Okada C, Nakamura A, Tanavde V, Yao M, Eom SH, Konigsberg WH, Soll D, Wang J. Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15235-40. Epub 2012 Sep 4. PMID:22949672 doi:https://dx.doi.org/10.1073/pnas.1213795109
