4k44 | pdb_00004k44
From Proteopedia
Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes
Function
[PLCG1_RAT] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).
About this Structure
4k44 is a 2 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.
Reference
- Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek JE. Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes. Biochemistry. 2013 Jun 18. PMID:23777354 doi:10.1021/bi400433b
