3m7o | pdb_00003m7o

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Template:STRUCTURE 3m7o

Crystal structure of mouse MD-1 in complex with phosphatidylcholine

Template:ABSTRACT PUBMED 20595044

Function

[LY86_MOUSE] May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.[1]

About this Structure

3m7o is a 4 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

Reference

  1. Harada H, Ohto U, Satow Y. Crystal structure of mouse MD-1 with endogenous phospholipid bound in its cavity. J Mol Biol. 2010 Jul 23;400(4):838-46. Epub 2010 Jun 1. PMID:20595044 doi:https://dx.doi.org/10.1016/j.jmb.2010.05.063
  1. ↑ Gorczynski RM, Chen Z, Clark DA, Hu J, Yu G, Li X, Tsang W, Hadidi S. Regulation of gene expression of murine MD-1 regulates subsequent T cell activation and cytokine production. J Immunol. 2000 Aug 15;165(4):1925-32. PMID:10925274

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