2z9k | pdb_00002z9k
Complex structure of SARS-CoV 3C-like protease with JMF1600
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Overview
Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.
About this Structure
2Z9K is a Single protein structure of sequence from Sars coronavirus with DMS and DOZ as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:17981158
Page seeded by OCA on Thu Feb 21 19:00:55 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Sars coronavirus
- Single protein
- Lee, C C.
- Wang, A H.
- DMS
- DOZ
- Atp-binding
- Complex
- Cytoplasm
- Endonuclease
- Exonuclease
- Helicase
- Hydrolase
- Membrane
- Metal-binding
- Nuclease
- Nucleotide-binding
- Nucleotidyltransferase
- Protease
- Ribosomal frameshift
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Thiol protease
- Transferase
- Transmembrane
- Zinc
- Zinc-finger
