3d8z | pdb_00003d8z

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Template:STRUCTURE 3d8z

RNase A- 5'-Deoxy-5'-N-pyrrolidinothymidine complex

Template:ABSTRACT PUBMED 19173562

Function

[RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.[1]

About this Structure

3d8z is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

See Also

Reference

  1. Samanta A, Leonidas DD, Dasgupta S, Pathak T, Zographos SE, Oikonomakos NG. Morpholino, Piperidino, and Pyrrolidino Derivatives of Pyrimidine Nucleosides as Inhibitors of Ribonuclease A: Synthesis, Biochemical, and Crystallographic Evaluation (#) (,) (dagger). J Med Chem. 2009 Jan 27. PMID:19173562 doi:10.1021/jm800724t
  1. ↑ delCardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. Protein Eng. 1995 Mar;8(3):261-73. PMID:7479688

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