3b2w | pdb_00003b2w
Crystal structure of pyrimidine amide 11 bound to Lck
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Overview
N-3-(Phenylcarbamoyl)arylpyrimidine-5-carboxamides are a novel class of selective Lck inhibitors. This series of compounds derives its selectivity from a hydrogen bond with the gatekeeper Thr316 of the enzyme. X-ray co-crystal structural data, structure-activity relationships, and the synthesis of these inhibitors are reported herein.
About this Structure
3B2W is a Single protein structure of sequence from Homo sapiens with 9NH as ligand. Active as Non-specific protein-tyrosine kinase, with EC number 2.7.10.2 Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR., Deak HL, Newcomb JR, Nunes JJ, Boucher C, Cheng AC, DiMauro EF, Epstein LF, Gallant P, Hodous BL, Huang X, Lee JH, Patel VF, Schneider S, Turci SM, Zhu X, Bioorg Med Chem Lett. 2008 Feb 1;18(3):1172-6. Epub 2007 Dec 5. PMID:18083554
Page seeded by OCA on Thu Feb 21 19:02:58 2008
Proteopedia Page Contributors and Editors (what is this?)
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- Homo sapiens
- Non-specific protein-tyrosine kinase
- Single protein
- Huang, X.
- 9NH
- Alternative splicing
- Atp-binding
- Chromosomal rearrangement
- Cytoplasm
- Disease mutation
- Host-virus interaction
- Kinase domain
- Lck
- Lipoprotein
- Membrane
- Myristate
- Nucleotide-binding
- Palmitate
- Phosphorylation
- Proto-oncogene
- Sh2 domain
- Sh3 domain
- Transferase
- Tyrosine-protein kinase
