4nan | pdb_00004nan
From Proteopedia
Arabidopsis thaliana IspD in complex with tetrabromo-pseudilin
Function
[ISPD_ARATH] Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis.[1] [2] [3]
About this Structure
4nan is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Rohdich F, Wungsintaweekul J, Eisenreich W, Richter G, Schuhr CA, Hecht S, Zenk MH, Bacher A. Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6451-6. PMID:10841550
- ↑ Okada K, Kawaide H, Kuzuyama T, Seto H, Curtis IS, Kamiya Y. Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. Planta. 2002 Jun;215(2):339-44. Epub 2002 Apr 12. PMID:12029484 doi:https://dx.doi.org/10.1007/s00425-002-0762-0
- ↑ Hsieh MH, Chang CY, Hsu SJ, Chen JJ. Chloroplast localization of methylerythritol 4-phosphate pathway enzymes and regulation of mitochondrial genes in ispD and ispE albino mutants in Arabidopsis. Plant Mol Biol. 2008 Apr;66(6):663-73. doi: 10.1007/s11103-008-9297-5. Epub 2008 , Jan 31. PMID:18236010 doi:https://dx.doi.org/10.1007/s11103-008-9297-5
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- Bacher, A.
- Diederich, F.
- Eisenreich, W.
- Fischer, M.
- Groll, M.
- Hoffken, H W.
- Illarionov, B.
- Knolker, H J.
- Kunfermann, A.
- Martin, R.
- Rottmann, M.
- Seet, M.
- Witschel, M.
- Allosteric inhibition
- Anti-infective
- Drug discovery
- Herbicide
- Natural product
- Pseudilin
- Rossmann fold
- Transferase
- Transferase-transferase inhibitor complex
