3dqb | pdb_00003dqb
Crystal structure of the active G-protein-coupled receptor opsin in complex with a C-terminal peptide derived from the Galpha subunit of transducin
Template:ABSTRACT PUBMED 18818650
Function
[OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).[1] [2] [GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
About this Structure
3dqb is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
See Also
Reference
- Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP. Crystal structure of opsin in its G-protein-interacting conformation. Nature. 2008 Sep 25;455(7212):497-502. PMID:18818650 doi:10.1038/nature07330
- ↑ Nakamichi H, Okada T. Local peptide movement in the photoreaction intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12729-34. Epub 2006 Aug 14. PMID:16908857
- ↑ Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607
Proteopedia Page Contributors and Editors (what is this?)
- Bos taurus
- Choe, H W.
- Ernst, O P.
- Hildebrand, P W.
- Hofmann, K P.
- Kim, Y J.
- Krauss, N.
- Park, J H.
- Scheerer, P.
- Chromophore
- G-protein
- G-protein coupled receptor
- G-protein-coupled receptor
- Galpha subunit
- Glycoprotein
- Gtp-binding
- Ligand-free state
- Lipoprotein
- Membrane
- Myristate
- Nucleotide-binding
- Opsin
- Palmitate
- Phosphoprotein
- Photoreceptor
- Photoreceptor protein
- Protein
- Receptor
- Retinal protein
- Rhodopsin
- Sensory transduction
- Signaling protein
- Transducer
- Transducin
- Transmembrane
- Vision
