3g2w | pdb_00003g2w

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Template:STRUCTURE 3g2w

VHS Domain of human GGA1 complexed with a DXXLL hinge peptide

Template:ABSTRACT PUBMED 20015111

Function

[GGA1_HUMAN] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.[1]

About this Structure

3g2w is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  1. Cramer JF, Gustafsen C, Behrens MA, Oliveira CL, Pedersen JS, Madsen P, Petersen CM, Thirup SS. GGA Autoinhibition Revisited. Traffic. 2010 Feb;11(2):259-73. Epub 2009 Nov 10. PMID:20015111 doi:https://dx.doi.org/TRA1017
  1. ↑ Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS. The GGAs promote ARF-dependent recruitment of clathrin to the TGN. Cell. 2001 Apr 6;105(1):93-102. PMID:11301005

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