4bv0 | pdb_00004bv0

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Template:STRUCTURE 4bv0

High Resolution Structure of Evolved Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion

Template:ABSTRACT PUBMED 24453215

Function

[NTR1_RAT] Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. [NEUT_RAT] Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

About this Structure

4bv0 is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schutz M, Pluckthun A. Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli. Proc Natl Acad Sci U S A. 2014 Jan 22. PMID:24453215 doi:https://dx.doi.org/10.1073/pnas.1317903111

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OCA

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