4lzb | pdb_00004lzb

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Template:STRUCTURE 4lzb

Uracil binding pocket in Vaccinia virus uracil DNA glycosylase

Template:ABSTRACT PUBMED 24316823

Function

[UNG_VACCA] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA.

About this Structure

4lzb is a 12 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Schormann N, Banerjee S, Ricciardi R, Chattopadhyay D. Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1328-34., doi: 10.1107/S1744309113030613. Epub 2013 Nov 28. PMID:24316823 doi:https://dx.doi.org/10.1107/S1744309113030613

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