4chf | pdb_00004chf

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Template:STRUCTURE 4chf

Crystal structure of the putative cap-binding domain of the PB2 subunit of Thogoto virus polymerase (form 2)

Template:ABSTRACT PUBMED 24454773

Function

[PB2_THOGV] Initiates transcription by a unique cap-stealing mechanism that involves the cleavage of only the m(7)GpppAm structure from cellular hnRNAs.

About this Structure

4chf is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Guilligay D, Kadlec J, Crepin T, Lunardi T, Bouvier D, Kochs G, Ruigrok RW, Cusack S. Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains. PLoS One. 2014 Jan 15;9(1):e84973. doi: 10.1371/journal.pone.0084973. eCollection, 2014 Jan 15. PMID:24454773 doi:https://dx.doi.org/10.1371/journal.pone.0084973

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