3loj | pdb_00003loj
From Proteopedia
Structure of Mycobacterium tuberculosis dUTPase H145A mutant
Function
[DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
About this Structure
3loj is a 1 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA.
See Also
Reference
- Pecsi I, Leveles I, Harmat V, Vertessy BG, Toth J. Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase. Nucleic Acids Res. 2010 Jul 2. PMID:20601405 doi:10.1093/nar/gkq584
