3bz9 | pdb_00003bz9
Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II
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Overview
Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.
About this Structure
3BZ9 is a Single protein structure of sequence from Dictyostelium discoideum with MG, VO4, ADP, BL7 and EDO as ligands. Known structural/functional Sites: AC1, AC2, AC3, AC4, AC5 and AC6. Full crystallographic information is available from OCA.
Reference
The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:15750603
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