4kcs | pdb_00004kcs

From Proteopedia
Revision as of 05:03, 13 February 2014 by OCA (talk | contribs)
Jump to navigationJump to search

Template:STRUCTURE 4kcs

Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-((ethyl(3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide

Template:ABSTRACT PUBMED 24447275

Function

[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

About this Structure

4kcs is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Huang H, Li H, Yang S, Chreifi G, Martasek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB. Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. J Med Chem. 2014 Jan 30. PMID:24447275 doi:https://dx.doi.org/10.1021/jm401252e

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=4kcs&oldid=1896552"