3rmj | pdb_00003rmj
From Proteopedia
Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis
Function
[LEU1_NEIMB] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity).
About this Structure
3rmj is a 2 chain structure with sequence from Neimi. Full crystallographic information is available from OCA.
Reference
- Huisman FH, Koon N, Bulloch EM, Baker HM, Baker EN, Squire CJ, Parker EJ. Removal of the C-Terminal Regulatory Domain of alpha-Isopropylmalate Synthase Disrupts Functional Substrate Binding. Biochemistry. 2012 Mar 6. PMID:22352945 doi:10.1021/bi201717j
