4hpc | pdb_00004hpc
From Proteopedia
Crystal structure of Nitrophorin 4 from Rhodnius prolixus Complexed with Cysteine at pH 7.4
Function
[NP4_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
About this Structure
4hpc is a 1 chain structure with sequence from Rhopr. Full crystallographic information is available from OCA.
Reference
- He C, Nishikawa K, Erdem OF, Reijerse E, Ogata H, Lubitz W, Knipp M. Complexes of ferriheme nitrophorin 4 with low-molecular weight thiol(ate)s occurring in blood plasma. J Inorg Biochem. 2013 May;122:38-48. doi: 10.1016/j.jinorgbio.2013.01.012. Epub, 2013 Feb 4. PMID:23474537 doi:https://dx.doi.org/10.1016/j.jinorgbio.2013.01.012
