4i14 | pdb_00004i14
From Proteopedia
Crystal Structure of Mtb-ribA2 (Rv1415)
Function
[RIBBA_MYCTA] Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity). Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity).
About this Structure
4i14 is a 2 chain structure with sequence from Mycta. Full crystallographic information is available from OCA.
Reference
- Singh M, Kumar P, Yadav S, Gautam R, Sharma N, Karthikeyan S. The crystal structure reveals the molecular mechanism of bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II (Rv1415) from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1633-44. doi:, 10.1107/S0907444913011402. Epub 2013 Aug 15. PMID:23999287 doi:https://dx.doi.org/10.1107/S0907444913011402
