4mwi | pdb_00004mwi

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Template:STRUCTURE 4mwi

Crystal structure of the human MLKL pseudokinase domain

Template:ABSTRACT PUBMED 24219132

Function

[MLKL_HUMAN] Required for the execution of programmed necrosis.[1]

About this Structure

4mwi is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  1. Murphy JM, Lucet IS, Hildebrand JM, Tanzer MC, Young SN, Sharma P, Lessene G, Alexander WS, Babon JJ, Silke J, Czabotar PE. Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL. Biochem J. 2013 Nov 13. PMID:24219132 doi:https://dx.doi.org/10.1042/BJ20131270
  1. ↑ Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell. 2012 Jan 20;148(1-2):228-43. doi: 10.1016/j.cell.2011.11.030. PMID:22265414 doi:https://dx.doi.org/10.1016/j.cell.2011.11.030

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