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Monoglyceride Lipase (MGL)

<StructureSection load= size='450' side='right' scene='58/580298/Overall_structure/1' caption='Secondary structure of MGL'>

Crystal Structure of MGL

Catalytic triad

MGL has a classic catalytic triad that contains Ser-His-Asp. This triad has a natural attraction to Endocannabinoids, specifically 2-arachidonylglycerol (2-AG). 2-AG contributes to brain signals (neurons) to suppress the pain pathways when a patient is feeling depressed or suffering from any type of pain.

Catalytic Triad of MGL structure

Ligand Binding Site

Ligand within the Overall Structure of MGL

Overall Reaction

Additional Resources

Serine hydrolases