4lxj | pdb_00004lxj

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Template:STRUCTURE 4lxj

Saccharomyces cerevisiae lanosterol 14-alpha demethylase with lanosterol bound

Template:ABSTRACT PUBMED 24613931

Function

[CP51_YEAST] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

About this Structure

4lxj is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD 3rd, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM. Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3865-70. doi:, 10.1073/pnas.1324245111. Epub 2014 Feb 3. PMID:24613931 doi:https://dx.doi.org/10.1073/pnas.1324245111

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