4ntj | pdb_00004ntj
From Proteopedia
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Disease
[P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.
Function
[P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.
About this Structure
4ntj is a 1 chain structure. Full crystallographic information is available from OCA.
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Cherezov, V.
- Fenalti, G.
- GPCR, GPCR Network.
- Gao, Z G.
- Han, G W.
- Jacobson, K A.
- Jiang, H.
- Katritch, V.
- Kiselev, E.
- Lu, W.
- Moss, S M.
- Muller, C E.
- Paoletta, S.
- Stevens, R C.
- Wu, B.
- Yang, H.
- Zhang, D.
- Zhang, J.
- Zhang, K.
- Zhang, W.
- Zhao, Q.
- Zhu, L.
- Antithrombotic drug
- Gpcr
- Gpcr network
- Human p2y12 receptor
- Lipidic cubic phase
- Membrane
- Membrane protein
- Psi-biology
- Signaling protein
- Structural genomic
