4nfm | pdb_00004nfm

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Template:STRUCTURE 4nfm

Human tau tubulin kinase 1 (TTBK1)

Template:ABSTRACT PUBMED 24637750

Function

[TTBK1_HUMAN] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.[1]

About this Structure

4nfm is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S. The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. Acta Crystallogr F Struct Biol Commun. 2014 Feb 1;70(Pt 2):173-81. doi:, 10.1107/S2053230X14000144. Epub 2014 Jan 21. PMID:24637750 doi:https://dx.doi.org/10.1107/S2053230X14000144
  1. ↑ Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem. 2006 Sep;98(5):1573-84. PMID:16923168 doi:JNC4059

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