4bpj | pdb_00004bpj
From Proteopedia
Mcl-1 bound to alpha beta Puma BH3 peptide 3
Template:ABSTRACT PUBMED 23929624
Function
[MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
About this Structure
4bpj is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Smith BJ, Lee EF, Checco JW, Evangelista M, Gellman SH, Fairlie WD. Structure-guided rational design of alpha/beta-peptide foldamers with high affinity for BCL-2 family prosurvival proteins. Chembiochem. 2013 Sep 2;14(13):1564-72. doi: 10.1002/cbic.201300351. Epub 2013, Aug 8. PMID:23929624 doi:https://dx.doi.org/10.1002/cbic.201300351
