1a37 | pdb_00001a37

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Template:STRUCTURE 1a37

14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE

Template:ABSTRACT PUBMED 9632691

Function

[1433Z_BOVIN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin.[1]

About this Structure

1a37 is a 4 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  1. Petosa C, Masters SC, Bankston LA, Pohl J, Wang B, Fu H, Liddington RC. 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J Biol Chem. 1998 Jun 26;273(26):16305-10. PMID:9632691
  1. ↑ Tanji M, Horwitz R, Rosenfeld G, Waymire JC. Activation of protein kinase C by purified bovine brain 14-3-3: comparison with tyrosine hydroxylase activation. J Neurochem. 1994 Nov;63(5):1908-16. PMID:7931346

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