1a3c | pdb_00001a3c
From Proteopedia
PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, DIMERIC FORM
Template:ABSTRACT PUBMED 9551555
Function
[PYRR_BACSU] Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.[HAMAP-Rule:MF_01219] Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.[HAMAP-Rule:MF_01219]
About this Structure
1a3c is a 1 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
- Tomchick DR, Turner RJ, Switzer RL, Smith JL. Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase. Structure. 1998 Mar 15;6(3):337-50. PMID:9551555
