2ymy | pdb_00002ymy

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Template:STRUCTURE 2ymy

Structure of the murine Nore1-Sarah domain

Template:ABSTRACT PUBMED 23331050

Function

[RASF5_MOUSE] Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.[1]

About this Structure

2ymy is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

Reference

  1. Makbul C, Constantinescu Aruxandei D, Hofmann E, Schwarz D, Wolf E, Herrmann C. Structural and Thermodynamic Characterization of Nore1-SARAH: A Small, Helical Module Important in Signal Transduction Networks. Biochemistry. 2013 Feb 12;52(6):1045-54. doi: 10.1021/bi3014642. Epub 2013 Jan, 30. PMID:23331050 doi:https://dx.doi.org/10.1021/bi3014642
  1. ↑ Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol. 2002 Feb 19;12(4):253-65. PMID:11864565

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