4ci8 | pdb_00004ci8

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Template:STRUCTURE 4ci8

Crystal structure of the tandem atypical beta-propeller domain of EML1

Template:ABSTRACT PUBMED 24706829

Function

[EMAL1_HUMAN] May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).

About this Structure

4ci8 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Richards MW, Law EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R. Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical beta-propeller domain. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5195-200. doi:, 10.1073/pnas.1322892111. Epub 2014 Mar 24. PMID:24706829 doi:https://dx.doi.org/10.1073/pnas.1322892111

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