4cml | pdb_00004cml
From Proteopedia
Crystal Structure of INPP5B in complex with Phosphatidylinositol 3,4- bisphosphate
Function
[I5P2_HUMAN] Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.[1]
About this Structure
4cml is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, Hammarstrom M, Berglund H, Nordlund P. Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases. Structure. 2014 Apr 2. pii: S0969-2126(14)00073-2. doi:, 10.1016/j.str.2014.01.013. PMID:24704254 doi:https://dx.doi.org/10.1016/j.str.2014.01.013
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Phosphoinositide 5-phosphatase
- Arrowsmith, C H.
- Berglund, H.
- Bountra, C.
- Edwards, A M.
- Ekblad, T.
- Flodin, S.
- Graslund, S.
- Karlberg, T.
- Moche, M.
- Nordlund, P.
- Nyman, T.
- Schuler, H.
- Silvander, C.
- Thorsell, A G.
- Tresaugues, L.
- Weigelt, J.
- Welin, M.
- Hydrolase
- Magnesium binding
- Sgc
- Signalling
- Structural genomics consortium stockholm
