1gve | pdb_00001gve
From Proteopedia
AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER
Template:ABSTRACT PUBMED 11839745
Function
[ARK73_RAT] Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Probably involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.[1]
About this Structure
1gve is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Kozma E, Brown E, Ellis EM, Lapthorn AJ. The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily. J Biol Chem. 2002 May 3;277(18):16285-93. Epub 2002 Feb 11. PMID:11839745 doi:10.1074/jbc.M110808200
- ↑ Kelly VP, Sherratt PJ, Crouch DH, Hayes JD. Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. Biochem J. 2002 Sep 15;366(Pt 3):847-61. PMID:12071861 doi:https://dx.doi.org/10.1042/BJ20020342
