1p33 | pdb_00001p33
From Proteopedia
Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX
Template:ABSTRACT PUBMED 12925782
Function
[PTR1_LEITA] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).
About this Structure
1p33 is a 4 chain structure with sequence from Leishmania tarentolae. Full crystallographic information is available from OCA.
See Also
Reference
- Zhao H, Bray T, Ouellette M, Zhao M, Ferre RA, Matthews D, Whiteley JM, Varughese KI. Structure of pteridine reductase (PTR1) from Leishmania tarentolae. Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1539-44. Epub 2003, Aug 19. PMID:12925782
