4pxt | pdb_00004pxt
From Proteopedia
Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers
Function
[KL61_DROME] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function.
About this Structure
4pxt is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Scholey JE, Nithianantham S, Scholey JM, Al-Bassam J. Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers. Elife. 2014 Apr 8;3:e02217. doi: 10.7554/eLife.02217. PMID:24714498
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Al-Bassam, J.
- Nithianantham, S.
- Scholey, J E.
- Scholey, J M.
- Anti-parallel four-helix bundle
- Bipolar assembly domain of kinesin-5
- Bipolar tetramer
- Cell cycle
- Coiled-coil
- Crosslinking adjacent microtubules into bundles throughout the mitotic spindle
- Kinesin-5 functions via a sliding filament mechanism
- Microtubule
