1vce | pdb_00001vce
From Proteopedia
Crystal structure of project ID PH0725 from Pyrococcus horikoshii OT3
Function
[DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.[1]
About this Structure
1vce is a 2 chain structure with sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.
See Also
Reference
- ↑ Zhu X, Kim J, Su X, Lin H. Reconstitution of diphthine synthase activity in vitro. Biochemistry. 2010 Nov 9;49(44):9649-57. doi: 10.1021/bi100812h. PMID:20873788 doi:https://dx.doi.org/10.1021/bi100812h
